AustralieFrV1, Main, Exploration, bibRecord, 00AB78

NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors

Identifieur interne : 00AB78 ( Main/Exploration ); précédent : 00AB77; suivant : 00AB79

NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors

Auteurs : Eugene Maraskovsky [Australie] ; Sigrid Sjölander [Australie] ; Debbie P. Drane [Australie] ; Max Schnurr [Australie] ; Thuy T. T. Le [Australie] ; Luis Mateo [Australie] ; Thomas Luft [Australie] ; Kelly-Anne Masterman [Australie] ; Tsin-Yee Tai [Australie] ; QIYUAN CHEN [Australie] ; Simon Green [Australie] ; Anders Sjölander [Australie] ; Martin J. Pearse [Australie] ; Francois A. Lemonnier [France] ; WEISAN CHEN [Australie] ; Jonathan Cebon [Australie] ; Andreas Suhrbier [Australie]

Source :

Clinical cancer research [ 1078-0432 ] ; 2004.

RBID : Pascal:04-0220235

Descripteurs français

Pascal (Inist)
- Adjuvant, Anticancéreux, Vaccin, Prévention, Immunité humorale, Lymphocyte T, Immunité cellulaire, Tumeur maligne, Antigène CD8.
Wicri :
- topic : Adjuvant, Vaccin.

English descriptors

KwdEn :
- Adjuvant, Antineoplastic agent, Cellular immunity, Humoral immunity, Malignant tumor, Prevention, T-Lymphocyte, Vaccine.

Abstract

NY-ESO-1 is a 180 amino-acid human tumor antigen expressed by many different tumor types and belongs to the family of "cancer-testis" antigens. In humans, NY-ESO-1 is one of the most immunogenic tumor antigens and NY-ESO-1 peptides have been shown to induce NY-ESO-1-specific CD8⁺ CTLS capable of altering the natural course of NY-ESO-1-expressing tumors in cancer patients. Here we describe the preclinical immunogenicity and efficacy of NY-ESO-1 protein formulated with the ISCOMATRIX adjuvant (NY-ESO-1 vaccine). In vitro, the NY-ESO-1 vaccine was readily taken up by human monocyte-derived dendritic cells, and on maturation, these human monocyte-derived dendritic cells efficiently cross-presented HLA-A2-restricted epitopes to NY-ESO-1-specific CD8⁺ T cells. In addition, epitopes of NY-ESO-1 protein were also presented on MHC class II molecules to NY-ESO-1-specific CD4⁺ T cells. The NY-ESO-1 vaccine induced strong NY-ESO-1-specific IFN-y and IgG2a responses in C57BL/6 mice. Furthermore, the NY-ESO-1 vaccine induced NY-ESO-1-specific CD8⁺ CTLs in HLA-A2 transgenic mice that were capable of lysing human HLA-A2⁺ NY-ESO-1⁺ tumor cells. Finally, C57BL/6 mice, immunized with the NY-ESO-1 vaccine, were protected against challenge with a B16 melanoma cell line expressing NY-ESO-1. These data illustrate that the NY-ESO-1 vaccine represents a potent therapeutic anticancer vaccine.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8<sup>+</sup>
 T-cell-mediated immunity and protection against NY-ESO-1<sup>+</sup>
 tumors</title>
<author><name sortKey="Maraskovsky, Eugene" sort="Maraskovsky, Eugene" uniqKey="Maraskovsky E" first="Eugene" last="Maraskovsky">Eugene Maraskovsky</name>
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<author><name sortKey="Masterman, Kelly Anne" sort="Masterman, Kelly Anne" uniqKey="Masterman K" first="Kelly-Anne" last="Masterman">Kelly-Anne Masterman</name>
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</author>
<author><name sortKey="Tai, Tsin Yee" sort="Tai, Tsin Yee" uniqKey="Tai T" first="Tsin-Yee" last="Tai">Tsin-Yee Tai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre (ARMC)</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qiyuan Chen" sort="Qiyuan Chen" uniqKey="Qiyuan Chen" last="Qiyuan Chen">QIYUAN CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre (ARMC)</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Green, Simon" sort="Green, Simon" uniqKey="Green S" first="Simon" last="Green">Simon Green</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CSL, Limited, Research & Development</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sjolander, Anders" sort="Sjolander, Anders" uniqKey="Sjolander A" first="Anders" last="Sjölander">Anders Sjölander</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CSL, Limited, Research & Development</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pearse, Martin J" sort="Pearse, Martin J" uniqKey="Pearse M" first="Martin J." last="Pearse">Martin J. Pearse</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CSL, Limited, Research & Development</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lemonnier, Francois A" sort="Lemonnier, Francois A" uniqKey="Lemonnier F" first="Francois A." last="Lemonnier">Francois A. Lemonnier</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute Pasteur, Departement-d'Immunologie, Unite d'Immunite Cellulaire Antivirale</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisan Chen" sort="Weisan Chen" uniqKey="Weisan Chen" last="Weisan Chen">WEISAN CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre (ARMC)</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cebon, Jonathan" sort="Cebon, Jonathan" uniqKey="Cebon J" first="Jonathan" last="Cebon">Jonathan Cebon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Ludwig Institute for Cancer Research, Austin and Repatriation Medical Centre (ARMC)</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical cancer research</title>
<title level="j" type="abbreviated">Clin. cancer res.</title>
<idno type="ISSN">1078-0432</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical cancer research</title>
<title level="j" type="abbreviated">Clin. cancer res.</title>
<idno type="ISSN">1078-0432</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvant</term>
<term>Antineoplastic agent</term>
<term>Cellular immunity</term>
<term>Humoral immunity</term>
<term>Malignant tumor</term>
<term>Prevention</term>
<term>T-Lymphocyte</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adjuvant</term>
<term>Anticancéreux</term>
<term>Vaccin</term>
<term>Prévention</term>
<term>Immunité humorale</term>
<term>Lymphocyte T</term>
<term>Immunité cellulaire</term>
<term>Tumeur maligne</term>
<term>Antigène CD8</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adjuvant</term>
<term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">NY-ESO-1 is a 180 amino-acid human tumor antigen expressed by many different tumor types and belongs to the family of "cancer-testis" antigens. In humans, NY-ESO-1 is one of the most immunogenic tumor antigens and NY-ESO-1 peptides have been shown to induce NY-ESO-1-specific CD8<sup>+</sup>
 CTLS capable of altering the natural course of NY-ESO-1-expressing tumors in cancer patients. Here we describe the preclinical immunogenicity and efficacy of NY-ESO-1 protein formulated with the ISCOMATRIX adjuvant (NY-ESO-1 vaccine). In vitro, the NY-ESO-1 vaccine was readily taken up by human monocyte-derived dendritic cells, and on maturation, these human monocyte-derived dendritic cells efficiently cross-presented HLA-A2-restricted epitopes to NY-ESO-1-specific CD8<sup>+</sup>
 T cells. In addition, epitopes of NY-ESO-1 protein were also presented on MHC class II molecules to NY-ESO-1-specific CD4<sup>+</sup>
 T cells. The NY-ESO-1 vaccine induced strong NY-ESO-1-specific IFN-y and IgG2a responses in C57BL/6 mice. Furthermore, the NY-ESO-1 vaccine induced NY-ESO-1-specific CD8<sup>+</sup>
 CTLs in HLA-A2 transgenic mice that were capable of lysing human HLA-A2<sup>+</sup>
 NY-ESO-1<sup>+</sup>
 tumor cells. Finally, C57BL/6 mice, immunized with the NY-ESO-1 vaccine, were protected against challenge with a B16 melanoma cell line expressing NY-ESO-1. These data illustrate that the NY-ESO-1 vaccine represents a potent therapeutic anticancer vaccine.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Maraskovsky, Eugene" sort="Maraskovsky, Eugene" uniqKey="Maraskovsky E" first="Eugene" last="Maraskovsky">Eugene Maraskovsky</name>
</noRegion>
<name sortKey="Cebon, Jonathan" sort="Cebon, Jonathan" uniqKey="Cebon J" first="Jonathan" last="Cebon">Jonathan Cebon</name>
<name sortKey="Drane, Debbie P" sort="Drane, Debbie P" uniqKey="Drane D" first="Debbie P." last="Drane">Debbie P. Drane</name>
<name sortKey="Green, Simon" sort="Green, Simon" uniqKey="Green S" first="Simon" last="Green">Simon Green</name>
<name sortKey="Le, Thuy T T" sort="Le, Thuy T T" uniqKey="Le T" first="Thuy T. T." last="Le">Thuy T. T. Le</name>
<name sortKey="Luft, Thomas" sort="Luft, Thomas" uniqKey="Luft T" first="Thomas" last="Luft">Thomas Luft</name>
<name sortKey="Maraskovsky, Eugene" sort="Maraskovsky, Eugene" uniqKey="Maraskovsky E" first="Eugene" last="Maraskovsky">Eugene Maraskovsky</name>
<name sortKey="Masterman, Kelly Anne" sort="Masterman, Kelly Anne" uniqKey="Masterman K" first="Kelly-Anne" last="Masterman">Kelly-Anne Masterman</name>
<name sortKey="Mateo, Luis" sort="Mateo, Luis" uniqKey="Mateo L" first="Luis" last="Mateo">Luis Mateo</name>
<name sortKey="Pearse, Martin J" sort="Pearse, Martin J" uniqKey="Pearse M" first="Martin J." last="Pearse">Martin J. Pearse</name>
<name sortKey="Qiyuan Chen" sort="Qiyuan Chen" uniqKey="Qiyuan Chen" last="Qiyuan Chen">QIYUAN CHEN</name>
<name sortKey="Schnurr, Max" sort="Schnurr, Max" uniqKey="Schnurr M" first="Max" last="Schnurr">Max Schnurr</name>
<name sortKey="Sjolander, Anders" sort="Sjolander, Anders" uniqKey="Sjolander A" first="Anders" last="Sjölander">Anders Sjölander</name>
<name sortKey="Sjolander, Sigrid" sort="Sjolander, Sigrid" uniqKey="Sjolander S" first="Sigrid" last="Sjölander">Sigrid Sjölander</name>
<name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name>
<name sortKey="Tai, Tsin Yee" sort="Tai, Tsin Yee" uniqKey="Tai T" first="Tsin-Yee" last="Tai">Tsin-Yee Tai</name>
<name sortKey="Weisan Chen" sort="Weisan Chen" uniqKey="Weisan Chen" last="Weisan Chen">WEISAN CHEN</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Lemonnier, Francois A" sort="Lemonnier, Francois A" uniqKey="Lemonnier F" first="Francois A." last="Lemonnier">Francois A. Lemonnier</name>
</region>
</country>
</tree>
</affiliations>
</record>

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NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors

NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors

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